Lexus RX 350 L
22 MPG The 2022 Lexus RX 350 L is EPA-rated at 22 MPG combined (19 city / 26 highway). Over 15,000 miles a year that is about 682 gallons, $2182 a year in fuel, or $0.145 per mile at $3.20/gal.
Across its full 2018–2022 run it averages 22 MPG, essentially flat across 5 model years.
Running cost at different fuel prices and mileages
The figure everyone actually wants, and the one the EPA does not publish — because it depends on a fuel price no agency will commit to.
| Fuel price | Per mile | 10,000 mi/yr | 15,000 mi/yr | 20,000 mi/yr |
|---|---|---|---|---|
| $2.50/gal | $0.114 | $1136 | $1705 | $2273 |
| $3.00/gal | $0.136 | $1364 | $2045 | $2727 |
| $3.20/gal | $0.145 | $1455 | $2182 | $2909 |
| $3.50/gal | $0.159 | $1591 | $2386 | $3182 |
| $4.00/gal | $0.182 | $1818 | $2727 | $3636 |
| $4.50/gal | $0.205 | $2045 | $3068 | $4091 |
| $5.00/gal | $0.227 | $2273 | $3409 | $4545 |
Every model year
| Year | Combined | City | Highway | EPA fuel cost/yr | CO₂ g/mi | Trims |
|---|---|---|---|---|---|---|
| 2022 | 22 MPG | 19 | 26 | $2850 | 407 | 1 |
| 2021 | 22 MPG | 19 | 26 | $2850 | 407 | 1 |
| 2020 | 22 MPG | 19 | 26 | $2850 | 407 | 1 |
| 2019 | 22 MPG | 19 | 26 | $2850 | 407 | 1 |
| 2018 | 22 MPG | 19 | 26 | $2850 | 407 | 1 |
Where a model year offered several engines or drivetrains, the figure is the average across all EPA-tested trims that year — the trim count is shown so you can see how much averaging is involved.
How it compares in its class
Among the 74 small sport utility vehicle 2wd models tracked here, the Lexus RX 350 L ranks 68 on current figures, against a class average of 34.8 MPG.
Closest more-efficient alternatives in the same class: Cadillac XT5 FWD (22.5), Acura RDX 2WD (23), Lincoln MKC FWD (23), Lincoln Nautilus FWD (23), Volkswagen Atlas Cross Sport (23).
Tailpipe CO₂ is rated at 407 grams per mile, which works out to roughly 6.1 tonnes a year at 15,000 miles.
Questions
What MPG does the Lexus RX 350 L get?
The 2022 Lexus RX 350 L is rated at 22 MPG combined by the EPA — 19 city and 26 highway. Across all 5 model years in the database it averages 22 MPG, ranging from 22 to 22 depending on year and trim.
How much does a Lexus RX 350 L cost in fuel per year?
At 22 MPG and 15,000 miles a year, it burns about 682 gallons — roughly $2182 a year with fuel at $3.20 a gallon, or $0.145 per mile. The EPA's own published annual figure for the 2022 model is $2850.
Has the Lexus RX 350 L become more efficient over time?
Barely. It sits at 22 MPG today against 22 in 2018 — essentially flat across 5 model years, with efficiency gains offset by weight and power creep.
Is the Lexus RX 350 L efficient for its class?
It ranks 68 of 74 in the Small Sport Utility Vehicle 2WD class on current figures, against a class average of 34.8 MPG. That is 12.8 worse than typical for the class.
EPA test figures from fueleconomy.gov. Cost per mile and annual fuel spend are computed at a reference price of $3.20 per gallon — use your own price. Estimates based on official test figures and average fuel prices. Real-world consumption varies with driving style, load, terrain and maintenance.