Mercedes-Benz E350 4matic
What it costs to keep fuelled
$1,778a year, fuel only
The 2026 Mercedes-Benz E350 4matic is EPA-rated at 27 MPG combined (24 city / 33 highway). Over 15,000 miles a year that is about 556 gallons, $1778 a year in fuel, or $0.119 per mile at $3.20/gal.
Across its full 2006–2026 run it averages 22.4 MPG, improving by 8 MPG over 18 model years.
The band is how far one gallon carries it: 27 of the 60 MPG this scale runs to. The square tick is the midsize cars average, 27.2.
- Fuel, per year
- $1,778 at 15,000 mi
- Per mile
- $0.119
- Per kilometre
- $0.074
- Gallons burned/yr
- 556
1 mile = 1.609344 km · fuel at $3.20/gal, fixed JUL 2026
Test figure — not a road resultSOURCE·US EPA fuel-economy test data·FUEL ASSUMED AT $3.20/GAL FROM JUL 2026·REVIEWED JUL 2026
How this is worked out
- Start from the EPA combined figure for the model year — a laboratory test cycle run to a fixed procedure, not a road result. Where a year sold several engines or drivetrains, the trims are averaged and the trim count is printed beside the row so you can see how much averaging is behind it.
- Fix a pump price. This site keeps one reference price, $3.20 a US gallon, fixed JUL 2026 and printed next to every dollar figure it produces. It is an assumption with a date on it, not a quote — put your own price in.
- Fix an annual distance. Every annual figure on this site uses 15,000 miles a year, roughly the US average. A cost per year with no stated distance is not a number, it is a mood.
- Divide distance by economy for gallons, multiply by price for the year's fuel, divide price by economy for one mile. The per-kilometre line is that last figure divided by 1.609344 — the same money, in the unit most of the world drives in.
- Stop there. No depreciation, no tyres, no insurance, no servicing. This is the fuel line of the ledger and it is labelled as one; depreciation usually dwarfs everything on it.
gallons/yr = miles/yr ÷ MPG fuel $/yr = gallons/yr × $/gal cost $/mi = $/gal ÷ MPG cost $/km = cost $/mi ÷ 1.609344
The full method, the licence note, and what a test figure cannot tell you →
Re-run the ledger at another pump price
Every line above rests on one pump price. Here is the same entry re-costed at six others, because the price is the part that changes while the test sheet stays put.
| Fuel price | Per mile | 10,000 mi/yr | 15,000 mi/yr | 20,000 mi/yr |
|---|---|---|---|---|
| $2.50/gal | $0.093 | $926 | $1389 | $1852 |
| $3.00/gal | $0.111 | $1111 | $1667 | $2222 |
| $3.20/gal | $0.119 | $1185 | $1778 | $2370 |
| $3.50/gal | $0.130 | $1296 | $1944 | $2593 |
| $4.00/gal | $0.148 | $1481 | $2222 | $2963 |
| $4.50/gal | $0.167 | $1667 | $2500 | $3333 |
| $5.00/gal | $0.185 | $1852 | $2778 | $3704 |
SOURCE·US EPA fuel-economy test data·FUEL ASSUMED AT $3.20/GAL FROM JUL 2026·REVIEWED JUL 2026
The whole service history, sheet by sheet
18 model years on file. Read down the combined column: a nameplate that got heavier shows it here long before any brochure admits it.
| Year | Combined | City | Highway | EPA fuel cost/yr | CO₂ g/mi | Trims |
|---|---|---|---|---|---|---|
| 2026 | 27 MPG | 24 | 33 | $2850 | 327 | 1 |
| 2025 | 27 MPG | 24 | 33 | $2850 | 327 | 1 |
| 2024 | 27 MPG | 24 | 33 | $2850 | 327 | 1 |
| 2023 | 24 MPG | 21 | 30 | $3200 | 364 | 1 |
| 2022 | 24 MPG | 21 | 29 | $3200 | 366 | 1 |
| 2021 | 25 MPG | 22 | 30 | $3100 | 355 | 1 |
| 2020 | 25 MPG | 22 | 30 | $3100 | 354 | 1 |
| 2016 | 23 MPG | 20 | 27 | $3350 | 384 | 2 |
| 2015 | 23 MPG | 20 | 27 | $3350 | 384 | 2 |
| 2014 | 22.7 MPG | 20 | 27.3 | $3400 | 389 | 3 |
| 2013 | 22 MPG | 19 | 28 | $3500 | 400 | 2 |
| 2012 | 22 MPG | 19 | 28 | $3500 | 404 | 1 |
| 2011 | 19 MPG | 17 | 24 | $4050 | 468 | 1 |
| 2010 | 19 MPG | 17 | 24 | $4050 | 468 | 1 |
| 2009 | 18 MPG | 16 | 22 | $4300 | 494 | 1 |
| 2008 | 18 MPG | 16 | 22 | $4300 | 494 | 1 |
| 2007 | 19 MPG | 16 | 23 | $4050 | 468 | 1 |
| 2006 | 19 MPG | 16 | 23 | $4050 | 468 | 1 |
Where a model year offered several engines or drivetrains, the figure is the average across all EPA-tested trims that year — the trim count is shown so you can see how much averaging is involved.
SOURCE·US EPA fuel-economy test data·FUEL ASSUMED AT $3.20/GAL FROM JUL 2026·REVIEWED JUL 2026
Marked against the rest of the midsize cars bay
Among the 261 midsize cars models tracked here, the Mercedes-Benz E350 4matic ranks 78 on current figures, against a class average of 27.2 MPG — the square tick on the gauge above.
Closest more-efficient alternatives in the same class: Kia Optima (27.3), Mazda 6 (27.5), MINI Cooper Clubman (27.5), Acura RLX Hybrid (28), Audi A6 (28).
Tailpipe CO₂ is rated at 327 grams per mile, which works out to roughly 4.9 tonnes a year at 15,000 miles.
Questions asked across the counter
What MPG does the Mercedes-Benz E350 4matic get?
The 2026 Mercedes-Benz E350 4matic is rated at 27 MPG combined by the EPA — 24 city and 33 highway. Across all 18 model years in the database it averages 22.4 MPG, ranging from 18 to 27 depending on year and trim.
How much does a Mercedes-Benz E350 4matic cost in fuel per year?
At 27 MPG and 15,000 miles a year, it burns about 556 gallons — roughly $1778 a year with fuel at $3.20 a gallon, or $0.119 per mile. The EPA's own published annual figure for the 2026 model is $2850.
Has the Mercedes-Benz E350 4matic become more efficient over time?
Yes. It has gone from 19 MPG in 2006 to 27 in 2026 — an improvement of 8 MPG, or 42% across 18 model years.
Is the Mercedes-Benz E350 4matic efficient for its class?
It ranks 78 of 261 in the Midsize Cars class on current figures, against a class average of 27.2 MPG. That is 0.2 worse than typical for the class.
Pull another logbook off the same shelf
Same class, nearest economy first — the ones a buyer is genuinely choosing between.
SOURCE·US EPA fuel-economy test data·FUEL ASSUMED AT $3.20/GAL FROM JUL 2026·REVIEWED JUL 2026
Cost per mile, per kilometre and per year are computed at a reference price of $3.20 a gallon over 15,000 miles, fixed JUL 2026 — set your own pump price. Estimates based on official test figures and average fuel prices. Real-world consumption varies with driving style, load, terrain and maintenance.
