Mercedes-Benz E450 4matic All-Terrain (wagon)
25 MPG The 2026 Mercedes-Benz E450 4matic All-Terrain (wagon) is EPA-rated at 25 MPG combined (22 city / 31 highway). Over 15,000 miles a year that is about 600 gallons, $1920 a year in fuel, or $0.128 per mile at $3.20/gal.
Across its full 2021–2026 run it averages 24.5 MPG, improving by 1 MPG over 6 model years.
Running cost at different fuel prices and mileages
The figure everyone actually wants, and the one the EPA does not publish — because it depends on a fuel price no agency will commit to.
| Fuel price | Per mile | 10,000 mi/yr | 15,000 mi/yr | 20,000 mi/yr |
|---|---|---|---|---|
| $2.50/gal | $0.100 | $1000 | $1500 | $2000 |
| $3.00/gal | $0.120 | $1200 | $1800 | $2400 |
| $3.20/gal | $0.128 | $1280 | $1920 | $2560 |
| $3.50/gal | $0.140 | $1400 | $2100 | $2800 |
| $4.00/gal | $0.160 | $1600 | $2400 | $3200 |
| $4.50/gal | $0.180 | $1800 | $2700 | $3600 |
| $5.00/gal | $0.200 | $2000 | $3000 | $4000 |
Every model year
| Year | Combined | City | Highway | EPA fuel cost/yr | CO₂ g/mi | Trims |
|---|---|---|---|---|---|---|
| 2026 | 25 MPG | 22 | 31 | $3100 | 351 | 1 |
| 2025 | 25 MPG | 22 | 31 | $3100 | 351 | 1 |
| 2024 | 25 MPG | 22 | 31 | $3100 | 351 | 1 |
| 2023 | 24 MPG | 21 | 28 | $3200 | 374 | 1 |
| 2022 | 24 MPG | 21 | 28 | $3200 | 368 | 1 |
| 2021 | 24 MPG | 22 | 28 | $3200 | 364 | 1 |
Where a model year offered several engines or drivetrains, the figure is the average across all EPA-tested trims that year — the trim count is shown so you can see how much averaging is involved.
How it compares in its class
Among the 26 midsize station wagons models tracked here, the Mercedes-Benz E450 4matic All-Terrain (wagon) ranks 3 on current figures, against a class average of 21.5 MPG.
Closest more-efficient alternatives in the same class: Ford Focus Station Wagon (26.5), Toyota Prius v (41).
Tailpipe CO₂ is rated at 351 grams per mile, which works out to roughly 5.3 tonnes a year at 15,000 miles.
Questions
What MPG does the Mercedes-Benz E450 4matic All-Terrain (wagon) get?
The 2026 Mercedes-Benz E450 4matic All-Terrain (wagon) is rated at 25 MPG combined by the EPA — 22 city and 31 highway. Across all 6 model years in the database it averages 24.5 MPG, ranging from 24 to 25 depending on year and trim.
How much does a Mercedes-Benz E450 4matic All-Terrain (wagon) cost in fuel per year?
At 25 MPG and 15,000 miles a year, it burns about 600 gallons — roughly $1920 a year with fuel at $3.20 a gallon, or $0.128 per mile. The EPA's own published annual figure for the 2026 model is $3100.
Has the Mercedes-Benz E450 4matic All-Terrain (wagon) become more efficient over time?
Yes. It has gone from 24 MPG in 2021 to 25 in 2026 — an improvement of 1 MPG, or 4% across 6 model years.
Is the Mercedes-Benz E450 4matic All-Terrain (wagon) efficient for its class?
It ranks 3 of 26 in the Midsize Station Wagons class on current figures, against a class average of 21.5 MPG. That is 3.5 better than typical for the class.
EPA test figures from fueleconomy.gov. Cost per mile and annual fuel spend are computed at a reference price of $3.20 per gallon — use your own price. Estimates based on official test figures and average fuel prices. Real-world consumption varies with driving style, load, terrain and maintenance.