Mercedes-Benz GLE350 4matic
22 MPG The 2026 Mercedes-Benz GLE350 4matic is EPA-rated at 22 MPG combined (19 city / 26 highway). Over 15,000 miles a year that is about 682 gallons, $2182 a year in fuel, or $0.145 per mile at $3.20/gal.
Across its full 2016–2026 run it averages 21.1 MPG, improving by 3 MPG over 10 model years.
Running cost at different fuel prices and mileages
The figure everyone actually wants, and the one the EPA does not publish — because it depends on a fuel price no agency will commit to.
| Fuel price | Per mile | 10,000 mi/yr | 15,000 mi/yr | 20,000 mi/yr |
|---|---|---|---|---|
| $2.50/gal | $0.114 | $1136 | $1705 | $2273 |
| $3.00/gal | $0.136 | $1364 | $2045 | $2727 |
| $3.20/gal | $0.145 | $1455 | $2182 | $2909 |
| $3.50/gal | $0.159 | $1591 | $2386 | $3182 |
| $4.00/gal | $0.182 | $1818 | $2727 | $3636 |
| $4.50/gal | $0.205 | $2045 | $3068 | $4091 |
| $5.00/gal | $0.227 | $2273 | $3409 | $4545 |
Every model year
| Year | Combined | City | Highway | EPA fuel cost/yr | CO₂ g/mi | Trims |
|---|---|---|---|---|---|---|
| 2026 | 22 MPG | 19 | 26 | $3500 | 410 | 1 |
| 2025 | 22 MPG | 19 | 26 | $3500 | 410 | 1 |
| 2024 | 23 MPG | 20 | 27 | $3350 | 384 | 1 |
| 2023 | 21 MPG | 20 | 24 | $3650 | 413 | 1 |
| 2022 | 22 MPG | 19 | 26 | $3500 | 402 | 1 |
| 2021 | 22 MPG | 19 | 26 | $3500 | 409 | 1 |
| 2020 | 22 MPG | 19 | 26 | $3500 | 404 | 1 |
| 2018 | 19 MPG | 18 | 22 | $4050 | 457 | 2 |
| 2017 | 19 MPG | 18 | 22 | $4050 | 457 | 2 |
| 2016 | 19 MPG | 18 | 22 | $4050 | 456 | 2 |
Where a model year offered several engines or drivetrains, the figure is the average across all EPA-tested trims that year — the trim count is shown so you can see how much averaging is involved.
How it compares in its class
Among the 130 small sport utility vehicle 4wd models tracked here, the Mercedes-Benz GLE350 4matic ranks 94 on current figures, against a class average of 29.3 MPG.
Closest more-efficient alternatives in the same class: Ford Edge AWD (22.3), Chevrolet Blazer AWD (22.5), Acura RDX AWD (23), Acura RDX AWD A-SPEC (23), Audi SQ5 (23).
Tailpipe CO₂ is rated at 410 grams per mile, which works out to roughly 6.2 tonnes a year at 15,000 miles.
Questions
What MPG does the Mercedes-Benz GLE350 4matic get?
The 2026 Mercedes-Benz GLE350 4matic is rated at 22 MPG combined by the EPA — 19 city and 26 highway. Across all 10 model years in the database it averages 21.1 MPG, ranging from 19 to 23 depending on year and trim.
How much does a Mercedes-Benz GLE350 4matic cost in fuel per year?
At 22 MPG and 15,000 miles a year, it burns about 682 gallons — roughly $2182 a year with fuel at $3.20 a gallon, or $0.145 per mile. The EPA's own published annual figure for the 2026 model is $3500.
Has the Mercedes-Benz GLE350 4matic become more efficient over time?
Yes. It has gone from 19 MPG in 2016 to 22 in 2026 — an improvement of 3 MPG, or 16% across 10 model years.
Is the Mercedes-Benz GLE350 4matic efficient for its class?
It ranks 94 of 130 in the Small Sport Utility Vehicle 4WD class on current figures, against a class average of 29.3 MPG. That is 7.3 worse than typical for the class.
Compare with similar models
EPA test figures from fueleconomy.gov. Cost per mile and annual fuel spend are computed at a reference price of $3.20 per gallon — use your own price. Estimates based on official test figures and average fuel prices. Real-world consumption varies with driving style, load, terrain and maintenance.