Mercedes-Benz GLS580 4matic
16 MPG The 2026 Mercedes-Benz GLS580 4matic is EPA-rated at 16 MPG combined (14 city / 20 highway). Over 15,000 miles a year that is about 938 gallons, $3000 a year in fuel, or $0.200 per mile at $3.20/gal.
Across its full 2020–2026 run it averages 17.1 MPG, falling by 2 MPG over 7 model years.
Running cost at different fuel prices and mileages
The figure everyone actually wants, and the one the EPA does not publish — because it depends on a fuel price no agency will commit to.
| Fuel price | Per mile | 10,000 mi/yr | 15,000 mi/yr | 20,000 mi/yr |
|---|---|---|---|---|
| $2.50/gal | $0.156 | $1563 | $2344 | $3125 |
| $3.00/gal | $0.188 | $1875 | $2813 | $3750 |
| $3.20/gal | $0.200 | $2000 | $3000 | $4000 |
| $3.50/gal | $0.219 | $2188 | $3281 | $4375 |
| $4.00/gal | $0.250 | $2500 | $3750 | $5000 |
| $4.50/gal | $0.281 | $2813 | $4219 | $5625 |
| $5.00/gal | $0.313 | $3125 | $4688 | $6250 |
Every model year
| Year | Combined | City | Highway | EPA fuel cost/yr | CO₂ g/mi | Trims |
|---|---|---|---|---|---|---|
| 2026 | 16 MPG | 14 | 20 | $4800 | 539 | 1 |
| 2025 | 16 MPG | 14 | 19 | $4800 | 548 | 1 |
| 2024 | 16 MPG | 14 | 20 | $4800 | 554 | 1 |
| 2023 | 18 MPG | 16 | 21 | $4300 | 499 | 1 |
| 2022 | 18 MPG | 16 | 21 | $4300 | 498 | 1 |
| 2021 | 18 MPG | 16 | 21 | $4300 | 491 | 1 |
| 2020 | 18 MPG | 16 | 21 | $4300 | 487 | 1 |
Where a model year offered several engines or drivetrains, the figure is the average across all EPA-tested trims that year — the trim count is shown so you can see how much averaging is involved.
How it compares in its class
Among the 105 standard sport utility vehicle 4wd models tracked here, the Mercedes-Benz GLS580 4matic ranks 78 on current figures, against a class average of 19.7 MPG.
Closest more-efficient alternatives in the same class: BMW Alpina XB7 (17), Chevrolet Tahoe K1500 4WD (17), GMC Yukon K1500 4WD (17), Infiniti QX80 4WD (17), Lincoln MKT AWD (17).
Tailpipe CO₂ is rated at 539 grams per mile, which works out to roughly 8.1 tonnes a year at 15,000 miles.
Questions
What MPG does the Mercedes-Benz GLS580 4matic get?
The 2026 Mercedes-Benz GLS580 4matic is rated at 16 MPG combined by the EPA — 14 city and 20 highway. Across all 7 model years in the database it averages 17.1 MPG, ranging from 16 to 18 depending on year and trim.
How much does a Mercedes-Benz GLS580 4matic cost in fuel per year?
At 16 MPG and 15,000 miles a year, it burns about 938 gallons — roughly $3000 a year with fuel at $3.20 a gallon, or $0.200 per mile. The EPA's own published annual figure for the 2026 model is $4800.
Has the Mercedes-Benz GLS580 4matic become more efficient over time?
No — it has actually gone backwards, from 18 MPG in 2020 to 16 in 2026. That usually reflects the model growing heavier, more powerful, or moving upmarket rather than the engineering getting worse.
Is the Mercedes-Benz GLS580 4matic efficient for its class?
It ranks 78 of 105 in the Standard Sport Utility Vehicle 4WD class on current figures, against a class average of 19.7 MPG. That is 3.7 worse than typical for the class.
EPA test figures from fueleconomy.gov. Cost per mile and annual fuel spend are computed at a reference price of $3.20 per gallon — use your own price. Estimates based on official test figures and average fuel prices. Real-world consumption varies with driving style, load, terrain and maintenance.