Mercedes-Benz S580 4matic
20 MPG The 2026 Mercedes-Benz S580 4matic is EPA-rated at 20 MPG combined (17 city / 27 highway). Over 15,000 miles a year that is about 750 gallons, $2400 a year in fuel, or $0.160 per mile at $3.20/gal.
Across its full 2021–2026 run it averages 19.8 MPG, essentially flat across 6 model years.
Running cost at different fuel prices and mileages
The figure everyone actually wants, and the one the EPA does not publish — because it depends on a fuel price no agency will commit to.
| Fuel price | Per mile | 10,000 mi/yr | 15,000 mi/yr | 20,000 mi/yr |
|---|---|---|---|---|
| $2.50/gal | $0.125 | $1250 | $1875 | $2500 |
| $3.00/gal | $0.150 | $1500 | $2250 | $3000 |
| $3.20/gal | $0.160 | $1600 | $2400 | $3200 |
| $3.50/gal | $0.175 | $1750 | $2625 | $3500 |
| $4.00/gal | $0.200 | $2000 | $3000 | $4000 |
| $4.50/gal | $0.225 | $2250 | $3375 | $4500 |
| $5.00/gal | $0.250 | $2500 | $3750 | $5000 |
Every model year
| Year | Combined | City | Highway | EPA fuel cost/yr | CO₂ g/mi | Trims |
|---|---|---|---|---|---|---|
| 2026 | 20 MPG | 17 | 27 | $3850 | 438 | 1 |
| 2025 | 20 MPG | 17 | 25 | $3850 | 448 | 1 |
| 2024 | 21 MPG | 18 | 27 | $3650 | 418 | 1 |
| 2023 | 19 MPG | 16 | 25 | $4050 | 459 | 1 |
| 2022 | 19 MPG | 16 | 25 | $4050 | 459 | 1 |
| 2021 | 20 MPG | 17 | 25 | $3850 | 452 | 1 |
Where a model year offered several engines or drivetrains, the figure is the average across all EPA-tested trims that year — the trim count is shown so you can see how much averaging is involved.
How it compares in its class
Among the 149 large cars models tracked here, the Mercedes-Benz S580 4matic ranks 52 on current figures, against a class average of 21.6 MPG.
Closest more-efficient alternatives in the same class: Dodge Intrepid (20.3), Buick Park Avenue (20.5), Genesis G80 AWD (20.5), BMW 535i xDrive Gran Turismo (21), BMW 750i (21).
Tailpipe CO₂ is rated at 438 grams per mile, which works out to roughly 6.6 tonnes a year at 15,000 miles.
Questions
What MPG does the Mercedes-Benz S580 4matic get?
The 2026 Mercedes-Benz S580 4matic is rated at 20 MPG combined by the EPA — 17 city and 27 highway. Across all 6 model years in the database it averages 19.8 MPG, ranging from 19 to 21 depending on year and trim.
How much does a Mercedes-Benz S580 4matic cost in fuel per year?
At 20 MPG and 15,000 miles a year, it burns about 750 gallons — roughly $2400 a year with fuel at $3.20 a gallon, or $0.160 per mile. The EPA's own published annual figure for the 2026 model is $3850.
Has the Mercedes-Benz S580 4matic become more efficient over time?
Barely. It sits at 20 MPG today against 20 in 2021 — essentially flat across 6 model years, with efficiency gains offset by weight and power creep.
Is the Mercedes-Benz S580 4matic efficient for its class?
It ranks 52 of 149 in the Large Cars class on current figures, against a class average of 21.6 MPG. That is 1.6 worse than typical for the class.
EPA test figures from fueleconomy.gov. Cost per mile and annual fuel spend are computed at a reference price of $3.20 per gallon — use your own price. Estimates based on official test figures and average fuel prices. Real-world consumption varies with driving style, load, terrain and maintenance.