Mercedes-Benz E350
28 MPG The 2026 Mercedes-Benz E350 is EPA-rated at 28 MPG combined (25 city / 33 highway). Over 15,000 miles a year that is about 536 gallons, $1714 a year in fuel, or $0.114 per mile at $3.20/gal.
Across its full 2006–2026 run it averages 23.1 MPG, improving by 8 MPG over 17 model years.
Running cost at different fuel prices and mileages
The figure everyone actually wants, and the one the EPA does not publish — because it depends on a fuel price no agency will commit to.
| Fuel price | Per mile | 10,000 mi/yr | 15,000 mi/yr | 20,000 mi/yr |
|---|---|---|---|---|
| $2.50/gal | $0.089 | $893 | $1339 | $1786 |
| $3.00/gal | $0.107 | $1071 | $1607 | $2143 |
| $3.20/gal | $0.114 | $1143 | $1714 | $2286 |
| $3.50/gal | $0.125 | $1250 | $1875 | $2500 |
| $4.00/gal | $0.143 | $1429 | $2143 | $2857 |
| $4.50/gal | $0.161 | $1607 | $2411 | $3214 |
| $5.00/gal | $0.179 | $1786 | $2679 | $3571 |
Every model year
| Year | Combined | City | Highway | EPA fuel cost/yr | CO₂ g/mi | Trims |
|---|---|---|---|---|---|---|
| 2026 | 28 MPG | 25 | 33 | $2750 | 316 | 1 |
| 2025 | 28 MPG | 25 | 33 | $2750 | 316 | 1 |
| 2023 | 26 MPG | 23 | 31 | $2950 | 342 | 1 |
| 2022 | 26 MPG | 23 | 31 | $2950 | 342 | 1 |
| 2021 | 25 MPG | 22 | 31 | $3100 | 349 | 1 |
| 2020 | 26 MPG | 23 | 32 | $2950 | 336 | 1 |
| 2016 | 23 MPG | 20 | 28.5 | $3350 | 378 | 2 |
| 2015 | 23 MPG | 20 | 28 | $3350 | 379 | 2 |
| 2014 | 23.3 MPG | 20 | 29 | $3300 | 382 | 3 |
| 2013 | 23 MPG | 19.7 | 29 | $3350 | 387 | 3 |
| 2012 | 23 MPG | 20 | 30 | $3350 | 386 | 1 |
| 2011 | 20 MPG | 17 | 25 | $3850 | 444 | 1 |
| 2010 | 21 MPG | 18 | 26 | $3650 | 423 | 1 |
| 2009 | 19 MPG | 17 | 24 | $4050 | 468 | 1 |
| 2008 | 19 MPG | 17 | 24 | $4050 | 468 | 1 |
| 2007 | 19 MPG | 17 | 24 | $4050 | 468 | 1 |
| 2006 | 20 MPG | 17 | 25 | $3850 | 444 | 1 |
Where a model year offered several engines or drivetrains, the figure is the average across all EPA-tested trims that year — the trim count is shown so you can see how much averaging is involved.
How it compares in its class
Among the 261 midsize cars models tracked here, the Mercedes-Benz E350 ranks 61 on current figures, against a class average of 27.2 MPG.
Closest more-efficient alternatives in the same class: Mazda 3 5-Door 2WD (28.5), Audi A5 Sportback quattro (29), Buick LaCrosse eAssist (29), MINI Cooper SE Countryman All4 (29), Nissan Altima SR (29).
Tailpipe CO₂ is rated at 316 grams per mile, which works out to roughly 4.7 tonnes a year at 15,000 miles.
Questions
What MPG does the Mercedes-Benz E350 get?
The 2026 Mercedes-Benz E350 is rated at 28 MPG combined by the EPA — 25 city and 33 highway. Across all 17 model years in the database it averages 23.1 MPG, ranging from 19 to 28 depending on year and trim.
How much does a Mercedes-Benz E350 cost in fuel per year?
At 28 MPG and 15,000 miles a year, it burns about 536 gallons — roughly $1714 a year with fuel at $3.20 a gallon, or $0.114 per mile. The EPA's own published annual figure for the 2026 model is $2750.
Has the Mercedes-Benz E350 become more efficient over time?
Yes. It has gone from 20 MPG in 2006 to 28 in 2026 — an improvement of 8 MPG, or 40% across 17 model years.
Is the Mercedes-Benz E350 efficient for its class?
It ranks 61 of 261 in the Midsize Cars class on current figures, against a class average of 27.2 MPG. That is 0.8 better than typical for the class.
EPA test figures from fueleconomy.gov. Cost per mile and annual fuel spend are computed at a reference price of $3.20 per gallon — use your own price. Estimates based on official test figures and average fuel prices. Real-world consumption varies with driving style, load, terrain and maintenance.