Mercedes-Benz E350 4matic (wagon)
22 MPG The 2016 Mercedes-Benz E350 4matic (wagon) is EPA-rated at 22 MPG combined (20 city / 26 highway). Over 15,000 miles a year that is about 682 gallons, $2182 a year in fuel, or $0.145 per mile at $3.20/gal.
Across its full 2006–2016 run it averages 20.1 MPG, improving by 4 MPG over 10 model years.
Running cost at different fuel prices and mileages
The figure everyone actually wants, and the one the EPA does not publish — because it depends on a fuel price no agency will commit to.
| Fuel price | Per mile | 10,000 mi/yr | 15,000 mi/yr | 20,000 mi/yr |
|---|---|---|---|---|
| $2.50/gal | $0.114 | $1136 | $1705 | $2273 |
| $3.00/gal | $0.136 | $1364 | $2045 | $2727 |
| $3.20/gal | $0.145 | $1455 | $2182 | $2909 |
| $3.50/gal | $0.159 | $1591 | $2386 | $3182 |
| $4.00/gal | $0.182 | $1818 | $2727 | $3636 |
| $4.50/gal | $0.205 | $2045 | $3068 | $4091 |
| $5.00/gal | $0.227 | $2273 | $3409 | $4545 |
Every model year
| Year | Combined | City | Highway | EPA fuel cost/yr | CO₂ g/mi | Trims |
|---|---|---|---|---|---|---|
| 2016 | 22 MPG | 20 | 26 | $3500 | 396 | 1 |
| 2015 | 22 MPG | 20 | 26 | $3500 | 396 | 1 |
| 2014 | 22 MPG | 20 | 26 | $3500 | 396 | 1 |
| 2013 | 22 MPG | 19 | 27 | $3500 | 415 | 1 |
| 2012 | 22 MPG | 19 | 27 | $3500 | 404 | 1 |
| 2011 | 19 MPG | 16 | 23 | $4050 | 468 | 1 |
| 2009 | 18 MPG | 16 | 21 | $4300 | 494 | 1 |
| 2008 | 18 MPG | 16 | 21 | $4300 | 494 | 1 |
| 2007 | 18 MPG | 16 | 22 | $4300 | 494 | 1 |
| 2006 | 18 MPG | 16 | 22 | $4300 | 494 | 1 |
Where a model year offered several engines or drivetrains, the figure is the average across all EPA-tested trims that year — the trim count is shown so you can see how much averaging is involved.
How it compares in its class
Among the 26 midsize station wagons models tracked here, the Mercedes-Benz E350 4matic (wagon) ranks 10 on current figures, against a class average of 21.6 MPG.
Closest more-efficient alternatives in the same class: Mercedes-Benz AMG GLB35 4matic (23), Nissan Murano AWD (23), Nissan Murano FWD (23), Volvo V90 CC AWD (24), Mercedes-Benz E450 4matic All-Terrain (wagon) (25).
Tailpipe CO₂ is rated at 396 grams per mile, which works out to roughly 5.9 tonnes a year at 15,000 miles.
Questions
What MPG does the Mercedes-Benz E350 4matic (wagon) get?
The 2016 Mercedes-Benz E350 4matic (wagon) is rated at 22 MPG combined by the EPA — 20 city and 26 highway. Across all 10 model years in the database it averages 20.1 MPG, ranging from 18 to 22 depending on year and trim.
How much does a Mercedes-Benz E350 4matic (wagon) cost in fuel per year?
At 22 MPG and 15,000 miles a year, it burns about 682 gallons — roughly $2182 a year with fuel at $3.20 a gallon, or $0.145 per mile. The EPA's own published annual figure for the 2016 model is $3500.
Has the Mercedes-Benz E350 4matic (wagon) become more efficient over time?
Yes. It has gone from 18 MPG in 2006 to 22 in 2016 — an improvement of 4 MPG, or 22% across 10 model years.
Is the Mercedes-Benz E350 4matic (wagon) efficient for its class?
It ranks 10 of 26 in the Midsize Station Wagons class on current figures, against a class average of 21.6 MPG. That is 0.4 better than typical for the class.
EPA test figures from fueleconomy.gov. Cost per mile and annual fuel spend are computed at a reference price of $3.20 per gallon — use your own price. Estimates based on official test figures and average fuel prices. Real-world consumption varies with driving style, load, terrain and maintenance.