Mercedes-Benz S500 4matic
23 MPG The 2026 Mercedes-Benz S500 4matic is EPA-rated at 23 MPG combined (20 city / 29 highway). Over 15,000 miles a year that is about 652 gallons, $2087 a year in fuel, or $0.139 per mile at $3.20/gal.
Across its full 2003–2026 run it averages 20.6 MPG, improving by 7 MPG over 10 model years.
Running cost at different fuel prices and mileages
The figure everyone actually wants, and the one the EPA does not publish — because it depends on a fuel price no agency will commit to.
| Fuel price | Per mile | 10,000 mi/yr | 15,000 mi/yr | 20,000 mi/yr |
|---|---|---|---|---|
| $2.50/gal | $0.109 | $1087 | $1630 | $2174 |
| $3.00/gal | $0.130 | $1304 | $1957 | $2609 |
| $3.20/gal | $0.139 | $1391 | $2087 | $2783 |
| $3.50/gal | $0.152 | $1522 | $2283 | $3043 |
| $4.00/gal | $0.174 | $1739 | $2609 | $3478 |
| $4.50/gal | $0.196 | $1957 | $2935 | $3913 |
| $5.00/gal | $0.217 | $2174 | $3261 | $4348 |
Every model year
| Year | Combined | City | Highway | EPA fuel cost/yr | CO₂ g/mi | Trims |
|---|---|---|---|---|---|---|
| 2026 | 23 MPG | 20 | 29 | $3350 | 380 | 1 |
| 2025 | 24 MPG | 21 | 31 | $3200 | 364 | 1 |
| 2024 | 24 MPG | 21 | 31 | $3200 | 364 | 1 |
| 2023 | 23 MPG | 20 | 28 | $3350 | 388 | 1 |
| 2022 | 24 MPG | 21 | 30 | $3200 | 372 | 1 |
| 2021 | 24 MPG | 20 | 29 | $3200 | 372 | 1 |
| 2006 | 16 MPG | 14 | 20 | $4800 | 555 | 1 |
| 2005 | 16 MPG | 14 | 20 | $4800 | 555 | 1 |
| 2004 | 16 MPG | 14 | 20 | $4800 | 555 | 1 |
| 2003 | 16 MPG | 14 | 19 | $4800 | 555 | 1 |
Where a model year offered several engines or drivetrains, the figure is the average across all EPA-tested trims that year — the trim count is shown so you can see how much averaging is involved.
How it compares in its class
Among the 149 large cars models tracked here, the Mercedes-Benz S500 4matic ranks 22 on current figures, against a class average of 21.5 MPG.
Closest more-efficient alternatives in the same class: BMW 740i (25), Toyota Avalon (25), Volkswagen Arteon 4motion (25), Genesis G80 RWD (26), Kia Forte 5 (26.7).
Tailpipe CO₂ is rated at 380 grams per mile, which works out to roughly 5.7 tonnes a year at 15,000 miles.
Questions
What MPG does the Mercedes-Benz S500 4matic get?
The 2026 Mercedes-Benz S500 4matic is rated at 23 MPG combined by the EPA — 20 city and 29 highway. Across all 10 model years in the database it averages 20.6 MPG, ranging from 16 to 24 depending on year and trim.
How much does a Mercedes-Benz S500 4matic cost in fuel per year?
At 23 MPG and 15,000 miles a year, it burns about 652 gallons — roughly $2087 a year with fuel at $3.20 a gallon, or $0.139 per mile. The EPA's own published annual figure for the 2026 model is $3350.
Has the Mercedes-Benz S500 4matic become more efficient over time?
Yes. It has gone from 16 MPG in 2003 to 23 in 2026 — an improvement of 7 MPG, or 44% across 10 model years.
Is the Mercedes-Benz S500 4matic efficient for its class?
It ranks 22 of 149 in the Large Cars class on current figures, against a class average of 21.5 MPG. That is 1.5 better than typical for the class.
EPA test figures from fueleconomy.gov. Cost per mile and annual fuel spend are computed at a reference price of $3.20 per gallon — use your own price. Estimates based on official test figures and average fuel prices. Real-world consumption varies with driving style, load, terrain and maintenance.